An adaptive response to alkylating agents in Aspergillus nidulans
نویسندگان
چکیده
منابع مشابه
Molecular characterization of an adaptive response to alkylating agents in the opportunistic pathogen Aspergillus fumigatus
An adaptive response to alkylating agents based upon the conformational change of a methylphosphotriester (MPT) DNA repair protein to a transcriptional activator has been demonstrated in a number of bacterial species, but this mechanism appears largely absent from eukaryotes. Here, we demonstrate that the human pathogen Aspergillus fumigatus elicits an adaptive response to sub-lethal doses of t...
متن کاملInduction of Mitotic Crossing-over in Aspergillus Nidulans by Bifunctional Alkylating Agents.
N previous researches, the ability of various mutagenic agents to induce somatic I crossing-over in diploids of Aspergillus nidulans has been studied ( MORPURGO 1963; STRIGINI, ROSSI and SERMONTI 1963). While X-rays and ultraviolet light and the decay of incorporated 3eP produced only a slight increase in crossing-over Irequency, methyl-bis (P-chloroethyl) amine (HN-2) induced somatic crossingo...
متن کاملAspergillus nidulans
Light-dependent conidiation in the filamentous ascomycete, Aspergillus nidulans, is contingent on the allelic state of the velvet (veA) gene. Light dependence is abolished by a mutation in this gene (veAl) , which allows conidiation to occur in the absence of light. We have isolated and characterized six extragenic suppressors of veAl that restore the light-dependent conidiation phenotype. Alle...
متن کاملMitosis in Aspergillus nidulans.
Mitosis in growing hyphae of haploid and diploid Aspergillus nidulans has been studied with the light microscope in Helly-fixed preparations. At the periphery of the nucleus a sharply defined granule is invariably found which has strong affinity for acid fuchsin. Mitosis begins with the duplication of this granule and the development inside the nucleus of a gradually lengthening fibre between t...
متن کاملResistance to various inhibitors in Aspergillus nidulans.
Resistant strains of Aspergillus nidulans were obtained by one-step selection on high concentrations of various inhibitors; each strain was mutant in a different gene conferring resistance to actidione (Act), p-fluorophenylalanine (p f ) , teoquil ( te) , iodoacetate (Iod) or malachite green (mg). Some mutant alleles have been firmly, others tentatively, located. For comparative purposes attemp...
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ژورنال
عنوان ژورنال: Current Genetics
سال: 1988
ISSN: 0172-8083,1432-0983
DOI: 10.1007/bf00521267